Express, purify and crystallize proteins for structure-based drug design and perform mass spectrometry on all products.Identify novel small-molecule drug candidates through in silico screening of commercially available chemical databases and molecular modeling of drug candidates for enhancement.Design, develop and deliver novel small molecule antibiotics against MDR organisms of military relevance through structure-based drug design.

Under the guidance of the Department head, the candidate will actively pursue the scientific objectives of the Branch and contribute significantly to the critical strategic planning and execution of future studies. The candidate will work independently and as part of a scientific team to understand and resolve complex biological questions while contributing to product development through the analysis and interpretation of data, presentation of data at meetings, the establishment of collaborations both internal and external to WRAIR, the solicitation of grants and the writing of successful proposals.

The candidate will perform a variety of laboratory procedures and be familiar with the field's concepts, practices, and procedures, including, but not limited to, microbiology, immunology, vaccinology, biochemistry, genetics, molecular biology, clinical trials, and bioinformatics. Researchers in this group express, purify and crystallize ESKAPEE pathogen proteins of interest and utilize sophisticated techniques such as X-ray Crystallography and Mass Spectroscopy to model small molecule drug-protein interactions Responsibilities The Structural Biology (XTAL) group focuses on structure-based drug designs for microbial pathogens of military relevance.

WID is tasked with delivering specific, effective countermeasures for infection of combat wounds pre-injury, at the point-of-injury, and post-injury. Scientist I to join a dynamic and growing team at the Walter Reed Army Institute of Research (WRAIR) Wound Infection Department (WID).

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